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Assay Detail

CHEMBL673899

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative effect against primary endothelial cells from pork aorta(ECPA)
18
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Sus scrofa
Cell Type Endothelial cell
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Synthesis and antiangiogenic activity of new carbohydrate derivatives
Dorey G, Leon P, Sciberras S, Leonce S, Guilbaud N, Pierre A, Atassi G, Billington D
Bioorg Med Chem Lett (1996) 6 : 3045 -3050
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.80 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL102592 1 6.10
CHEMBL105241 1 5.62
CHEMBL104243 1 4.80
CHEMBL317452 1 4.64
CHEMBL321348 1 4.24
CHEMBL318967 2 4.17
CHEMBL104162 1 -
CHEMBL104342 1 -
CHEMBL320894 1 -
CHEMBL318100 2 -
CHEMBL105341 1 -
CHEMBL103781 1 -
CHEMBL322884 1 -
CHEMBL105900 1 -
CHEMBL105653 1 -
CHEMBL102997 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL102592 IC50 = 800.0 nM 6.10
CHEMBL105241 IC50 = 2400.0 nM 5.62
CHEMBL104243 IC50 = 16000.0 nM 4.80
CHEMBL317452 IC50 = 23000.0 nM 4.64
CHEMBL321348 IC50 = 57000.0 nM 4.24
CHEMBL318967 IC50 = 68000.0 nM 4.17
CHEMBL318967 IC50 = 90000.0 nM 4.05
CHEMBL104162 IC50 = 343000.0 nM -
CHEMBL104342 IC50 = 122000.0 nM -
CHEMBL320894 IC50 = 398000.0 nM -
CHEMBL318100 IC50 = 124000.0 nM -
CHEMBL318100 IC50 = 178000.0 nM -
CHEMBL103781 IC50 = 195000.0 nM -
CHEMBL322884 IC50 > 500000.0 nM -
CHEMBL105900 IC50 = 175000.0 nM -
CHEMBL105653 IC50 = 278000.0 nM -
CHEMBL102997 IC50 = 363000.0 nM -
CHEMBL105341 IC50 = 119000.0 nM -