Assay Detail
Functional
CHEMBL673911
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Effective concentration for 50% inhibition of endothelial cell- based plasminogen activator activity relative to control by beta-PDBu stimulation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Endothelial cell |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.84 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311543 | — | — | 1 | 6.62 |
| CHEMBL419866 | — | — | 1 | 6.26 |
| CHEMBL328229 | — | — | 1 | 5.37 |
| CHEMBL316239 | — | — | 1 | 5.12 |
| CHEMBL315389 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311543 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL419866 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL328229 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL316239 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL315389 | — | EC50 | > | 2000.0 | nM | - |