Assay Detail
Binding
CHEMBL673925
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phosphorylation of a polyglutamic acid/tyrosine random copolymer by EGFR enzyme (from human A431 carcinoma cell vesicles)
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 18. 6-Substituted 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as soluble, irreversible inhibitors of the epidermal growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 8.88 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334697 | — | — | 1 | 9.77 |
| CHEMBL134371 | — | — | 1 | 9.43 |
| CHEMBL336264 | — | — | 1 | 9.37 |
| CHEMBL345109 | — | — | 1 | 9.36 |
| CHEMBL136404 | — | — | 1 | 9.30 |
| CHEMBL93464 | — | — | 1 | 9.26 |
| CHEMBL342828 | — | — | 1 | 9.25 |
| CHEMBL138940 | — | — | 1 | 9.21 |
| CHEMBL344177 | — | — | 1 | 9.16 |
| CHEMBL285063 | — | — | 1 | 9.15 |
| CHEMBL434827 | — | — | 1 | 9.14 |
| CHEMBL139095 | — | — | 1 | 9.12 |
| CHEMBL136058 | — | — | 1 | 9.09 |
| CHEMBL51659 | — | — | 1 | 9.04 |
| CHEMBL334801 | — | — | 1 | 8.96 |
| CHEMBL139044 | — | — | 1 | 8.96 |
| CHEMBL136178 | — | — | 1 | 8.92 |
| CHEMBL92086 | — | — | 1 | 8.92 |
| CHEMBL136511 | — | — | 1 | 8.85 |
| CHEMBL136102 | — | — | 1 | 8.84 |
| CHEMBL422292 | — | — | 1 | 8.82 |
| CHEMBL545315 | CANERTINIB DIHYDROCHLORIDE | 3.0 | 1 | 8.82 |
| CHEMBL343722 | — | — | 1 | 8.80 |
| CHEMBL138363 | — | — | 1 | 8.80 |
| CHEMBL135142 | — | — | 1 | 8.76 |
| CHEMBL140561 | — | — | 1 | 8.62 |
| CHEMBL344486 | — | — | 1 | 8.57 |
| CHEMBL137082 | — | — | 1 | 8.57 |
| CHEMBL139307 | — | — | 1 | 8.48 |
| CHEMBL138691 | — | — | 1 | 8.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334697 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL134371 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL336264 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL345109 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL136404 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL93464 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL342828 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL138940 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL344177 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL285063 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL434827 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL139095 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL136058 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL51659 | — | IC50 | = | 0.91 | nM | 9.04 |
| CHEMBL139044 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL334801 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL136178 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL92086 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL136511 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL136102 | — | IC50 | = | 1.45 | nM | 8.84 |
| CHEMBL422292 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL545315 | CANERTINIB DIHYDROCHLORIDE | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL343722 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL138363 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL135142 | — | IC50 | = | 1.75 | nM | 8.76 |
| CHEMBL140561 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL344486 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL137082 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL139307 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL138691 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL345077 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL434828 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL335440 | — | IC50 | = | 93.5 | nM | 7.03 |