Assay Detail
Binding
CHEMBL673935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity Sprague-Dawley rats using [3H]WIN-35428 ligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.39 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 7.92 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.73 |
| CHEMBL314726 | — | — | 1 | 4.52 |
| CHEMBL2112790 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL370805 | COCAINE | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL314726 | — | Ki | = | 30300.0 | nM | 4.52 |
| CHEMBL2112790 | — | Ki | = | 174000.0 | nM | - |