Assay Detail
Binding
CHEMBL673943
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]GBR-12935 binding to the dopamine transporter.
6
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.96 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177269 | — | — | 1 | 6.60 |
| CHEMBL352575 | — | — | 3 | 6.28 |
| CHEMBL120901 | — | — | 1 | 6.16 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177269 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL352575 | — | IC50 | = | 525.0 | nM | 6.28 |
| CHEMBL120901 | — | IC50 | = | 687.0 | nM | 6.16 |
| CHEMBL370805 | COCAINE | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL352575 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL352575 | — | IC50 | = | 5200.0 | nM | 5.28 |