Assay Detail
Binding
CHEMBL674012
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibition of EGF-receptor tyrosine kinase in intact cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.16 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169757 | — | — | 1 | 5.52 |
| CHEMBL424375 | — | — | 1 | 5.19 |
| CHEMBL105436 | — | — | 1 | 5.00 |
| CHEMBL173478 | — | — | 1 | 4.92 |
| CHEMBL172973 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169757 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL424375 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL105436 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL173478 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL172973 | — | IC50 | > | 10000.0 | nM | - |