Assay Detail
Binding
CHEMBL674017
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Inhibition of EGF-stimulated autophosphorylation of epidermal growth factor receptor (EGFR) in A431 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.13 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54091 | — | — | 1 | 8.68 |
| CHEMBL280757 | — | — | 1 | 8.57 |
| CHEMBL31373 | — | — | 1 | 8.51 |
| CHEMBL53555 | — | — | 1 | 8.48 |
| CHEMBL51659 | — | — | 1 | 8.47 |
| CHEMBL285063 | — | — | 1 | 8.37 |
| CHEMBL296168 | — | — | 1 | 8.25 |
| CHEMBL54088 | — | — | 1 | 8.08 |
| CHEMBL51741 | — | — | 1 | 8.00 |
| CHEMBL443523 | — | — | 1 | 7.85 |
| CHEMBL53665 | — | — | 1 | 7.75 |
| CHEMBL28418 | — | — | 1 | 7.75 |
| CHEMBL49986 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54091 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL280757 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL31373 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL53555 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL51659 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL285063 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL296168 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL54088 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL51741 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL443523 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL53665 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL28418 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL49986 | — | IC50 | = | 108.0 | nM | 6.97 |