Assay Detail
Binding
CHEMBL674018
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Inhibition of phosphorylation of glutamic acid/tyrosine random copolymer by isolated epidermal growth factor receptor (EGFR)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 9.16 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51741 | — | — | 1 | 9.40 |
| CHEMBL443523 | — | — | 1 | 9.35 |
| CHEMBL54088 | — | — | 1 | 9.32 |
| CHEMBL49986 | — | — | 1 | 9.27 |
| CHEMBL280757 | — | — | 1 | 9.16 |
| CHEMBL285063 | — | — | 1 | 9.15 |
| CHEMBL54091 | — | — | 1 | 9.14 |
| CHEMBL28418 | — | — | 1 | 9.12 |
| CHEMBL31373 | — | — | 1 | 9.12 |
| CHEMBL53555 | — | — | 1 | 9.11 |
| CHEMBL51659 | — | — | 1 | 9.04 |
| CHEMBL296168 | — | — | 1 | 8.96 |
| CHEMBL53665 | — | — | 1 | 8.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51741 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL443523 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL54088 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL49986 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL280757 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL285063 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL54091 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL28418 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL31373 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL53555 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL51659 | — | IC50 | = | 0.91 | nM | 9.04 |
| CHEMBL296168 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL53665 | — | IC50 | = | 1.2 | nM | 8.92 |