Assay Detail
Binding
CHEMBL674019
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Inhibition of EGF-stimulated autophosphorylation of EGFR enzyme in A431 cells detected by immunoblotting
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | A-431 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.37 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280757 | — | — | 1 | 8.57 |
| CHEMBL285063 | — | — | 1 | 8.57 |
| CHEMBL32844 | — | — | 1 | 8.52 |
| CHEMBL31373 | — | — | 1 | 8.51 |
| CHEMBL27685 | — | — | 1 | 8.33 |
| CHEMBL31815 | — | — | 1 | 8.33 |
| CHEMBL31419 | — | — | 1 | 8.28 |
| CHEMBL31965 | CANERTINIB | 3.0 | 1 | 8.13 |
| CHEMBL31588 | — | — | 1 | 8.10 |
| CHEMBL28418 | — | — | 1 | 7.75 |
| CHEMBL31622 | — | — | 1 | 7.75 |
| CHEMBL286343 | — | — | 1 | 7.68 |
| CHEMBL27688 | — | — | 1 | 7.57 |
| CHEMBL31630 | — | — | 1 | 7.06 |
| CHEMBL417478 | — | — | 1 | 6.92 |
| CHEMBL31326 | — | — | 1 | 6.71 |
| CHEMBL284326 | — | — | 1 | 6.58 |
| CHEMBL31816 | — | — | 1 | 6.54 |
| CHEMBL31570 | — | — | 1 | 6.42 |
| CHEMBL283201 | — | — | 1 | 6.38 |
| CHEMBL31656 | — | — | 1 | 6.36 |
| CHEMBL281543 | — | — | 1 | 5.29 |
| CHEMBL31369 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280757 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL285063 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL32844 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL31373 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL27685 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL31815 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL31419 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL31965 | CANERTINIB | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL31588 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL28418 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL31622 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL286343 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL27688 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL31630 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL417478 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL31326 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL284326 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL31816 | — | IC50 | = | 291.0 | nM | 6.54 |
| CHEMBL31570 | — | IC50 | = | 377.0 | nM | 6.42 |
| CHEMBL283201 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL31656 | — | IC50 | = | 434.0 | nM | 6.36 |
| CHEMBL281543 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL31369 | — | IC50 | = | 7693.0 | nM | 5.11 |