Assay Detail
Binding
CHEMBL674104
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Inhibition of Epidermal growth factor receptor autophosphorylation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.09 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56543 | — | — | 1 | 7.00 |
| CHEMBL53898 | — | — | 1 | 6.16 |
| CHEMBL56731 | — | — | 1 | 5.90 |
| CHEMBL440298 | — | — | 1 | 5.30 |
| CHEMBL293749 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56543 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL53898 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL56731 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL440298 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL293749 | — | IC50 | < | 625.0 | nM | - |