Assay Detail
Binding
CHEMBL674112
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]mazindol binding to the dopamine transporter.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.57 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL610897 | — | — | 1 | 8.70 |
| CHEMBL3143431 | — | — | 1 | 6.75 |
| CHEMBL120901 | — | — | 1 | 6.41 |
| CHEMBL352575 | — | — | 1 | 6.19 |
| CHEMBL1947052 | — | — | 1 | 4.82 |
| CHEMBL367502 | — | — | 1 | - |
| CHEMBL1790051 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL610897 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3143431 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL120901 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL352575 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1947052 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL367502 | — | IC50 | = | 342000.0 | nM | - |
| CHEMBL1790051 | — | IC50 | = | 385000.0 | nM | - |