Assay Detail
Binding
CHEMBL674113
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]dopamine uptake at dopamine transporter.
12
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.05 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177269 | — | — | 1 | 7.11 |
| CHEMBL369375 | — | — | 1 | 6.66 |
| CHEMBL352575 | — | — | 4 | 6.50 |
| CHEMBL174568 | — | — | 1 | 6.10 |
| CHEMBL120901 | — | — | 3 | 6.06 |
| CHEMBL369016 | — | — | 1 | 5.85 |
| CHEMBL3143431 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177269 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL369375 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL352575 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL352575 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL174568 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL352575 | — | IC50 | = | 815.0 | nM | 6.09 |
| CHEMBL120901 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL369016 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL352575 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL3143431 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL120901 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL120901 | — | IC50 | = | 5020.0 | nM | 5.30 |