Assay Detail
Binding
CHEMBL674114
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of dopamine uptake at dopamine transporter.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.40 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL610897 | — | — | 1 | 7.52 |
| CHEMBL2310852 | — | — | 1 | 6.70 |
| CHEMBL607198 | — | — | 1 | 6.25 |
| CHEMBL1237136 | — | — | 1 | 6.21 |
| CHEMBL177595 | — | — | 1 | 6.04 |
| CHEMBL1790051 | — | — | 1 | 5.68 |
| CHEMBL1947052 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL610897 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2310852 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL607198 | — | IC50 | = | 557.0 | nM | 6.25 |
| CHEMBL1237136 | — | IC50 | = | 616.0 | nM | 6.21 |
| CHEMBL177595 | — | IC50 | = | 903.0 | nM | 6.04 |
| CHEMBL1790051 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1947052 | — | IC50 | = | 186000.0 | nM | - |