Assay Detail
Binding
CHEMBL674242
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Inhibition of human dopamine receptor D1
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
From hit to lead. Analyzing structure-profile relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.75 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116463 | — | — | 1 | 6.42 |
| CHEMBL113956 | — | — | 1 | 6.01 |
| CHEMBL326263 | — | — | 1 | 5.95 |
| CHEMBL114280 | — | — | 1 | 5.60 |
| CHEMBL117537 | — | — | 1 | 5.56 |
| CHEMBL114484 | — | — | 1 | 5.56 |
| CHEMBL115444 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116463 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL113956 | — | IC50 | = | 967.0 | nM | 6.01 |
| CHEMBL326263 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL114280 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL117537 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL114484 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL115444 | — | IC50 | = | 7580.0 | nM | 5.12 |