Assay Detail
Binding
CHEMBL674251
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Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
trans-2,6-,3,6- and 4,6-diaza-5,6,6a,7,8,12b-hexahydro-benzo[c]phenanthrene-10,11- diols as dopamine agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.73 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25856 | DIHYDREXIDINE | 2.0 | 1 | 7.48 |
| CHEMBL26965 | — | — | 1 | 7.35 |
| CHEMBL28338 | A-86929 | -1.0 | 1 | 7.31 |
| CHEMBL285924 | — | — | 1 | 7.31 |
| CHEMBL281932 | — | — | 1 | 7.19 |
| CHEMBL27117 | — | — | 1 | 6.85 |
| CHEMBL284644 | — | — | 1 | 6.85 |
| CHEMBL27101 | — | — | 1 | 6.75 |
| CHEMBL275379 | — | — | 1 | 6.62 |
| CHEMBL284959 | — | — | 1 | 6.55 |
| CHEMBL26365 | — | — | 1 | 6.41 |
| CHEMBL287513 | — | — | 1 | 6.25 |
| CHEMBL283247 | — | — | 1 | 6.05 |
| CHEMBL28054 | — | — | 1 | 5.96 |
| CHEMBL282136 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25856 | DIHYDREXIDINE | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL26965 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL28338 | A-86929 | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL285924 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL281932 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL27117 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL284644 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL27101 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL275379 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL284959 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL26365 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL287513 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL283247 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL28054 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL282136 | — | Ki | = | 1100.0 | nM | 5.96 |