Assay Detail
Binding
CHEMBL674262
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Ability to displace [3H]- beta-CIT from Dopamine transporter in rat striatal homogenate
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.36 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14613 | — | — | 1 | 9.19 |
| CHEMBL318961 | — | — | 1 | 9.03 |
| CHEMBL311347 | — | — | 1 | 8.88 |
| CHEMBL105693 | — | — | 1 | 8.81 |
| CHEMBL433159 | — | — | 1 | 8.48 |
| CHEMBL430504 | — | — | 1 | 8.14 |
| CHEMBL318755 | — | — | 1 | 8.08 |
| CHEMBL317444 | — | — | 1 | 8.06 |
| CHEMBL105089 | — | — | 1 | 7.49 |
| CHEMBL319052 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14613 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL318961 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL311347 | — | Ki | = | 1.33 | nM | 8.88 |
| CHEMBL105693 | — | Ki | = | 1.54 | nM | 8.81 |
| CHEMBL433159 | — | Ki | = | 3.33 | nM | 8.48 |
| CHEMBL430504 | — | Ki | = | 7.17 | nM | 8.14 |
| CHEMBL318755 | — | Ki | = | 8.29 | nM | 8.08 |
| CHEMBL317444 | — | Ki | = | 8.71 | nM | 8.06 |
| CHEMBL105089 | — | Ki | = | 32.1 | nM | 7.49 |
| CHEMBL319052 | — | Ki | = | 37.6 | nM | 7.42 |