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Assay Detail

CHEMBL674340

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland
2
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

D(1A) dopamine receptor (CHEMBL2967)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Development of a high affinity and stereoselective photoaffinity label for the D-1 dopamine receptor: synthesis and resolution of 7-[125I]iodo-8-hydroxy-3-methyl-1-(4'-azidophenyl)-2,3,4,5-tetrahydro- 1H-3-benzazepine.
Neumeyer JL, Baindur N, Yuan J, Booth G, Seeman P, Niznik HB.
J Med Chem (1990) 33 : 521 -526
PubMed 2405157 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 8.78 9.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL62 SCH-23390 2 9.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL62 SCH-23390 Ki = 0.16 nM 9.80
CHEMBL62 SCH-23390 Ki = 18.0 nM 7.75