Assay Detail
Binding
CHEMBL674427
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Affinity at rat dopamine transporter using [125I]RTI-55 displacement.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 8.42 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416409 | — | — | 1 | 9.15 |
| CHEMBL409161 | — | — | 1 | 8.96 |
| CHEMBL35122 | — | — | 1 | 8.96 |
| CHEMBL36141 | — | — | 1 | 8.92 |
| CHEMBL34591 | — | — | 1 | 8.92 |
| CHEMBL290799 | — | — | 1 | 8.92 |
| CHEMBL284096 | — | — | 1 | 8.68 |
| CHEMBL36419 | — | — | 1 | 8.64 |
| CHEMBL34697 | — | — | 1 | 8.60 |
| CHEMBL35005 | — | — | 1 | 8.46 |
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 8.43 |
| CHEMBL33902 | — | — | 1 | 8.42 |
| CHEMBL20648 | — | — | 1 | 8.29 |
| CHEMBL35239 | — | — | 1 | 8.24 |
| CHEMBL285673 | — | — | 1 | 8.24 |
| CHEMBL33903 | — | — | 1 | 8.19 |
| CHEMBL36074 | — | — | 1 | 8.14 |
| CHEMBL35045 | — | — | 1 | 8.10 |
| CHEMBL34032 | — | — | 1 | 8.00 |
| CHEMBL289013 | — | — | 1 | 7.88 |
| CHEMBL35411 | — | — | 1 | 7.80 |
| CHEMBL34372 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416409 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL409161 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL35122 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL36141 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL34591 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL290799 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL284096 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL36419 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL34697 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL35005 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL281594 | VANOXERINE | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL33902 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL20648 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL35239 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL285673 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL33903 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL36074 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL35045 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL34032 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL289013 | — | Ki | = | 13.3 | nM | 7.88 |
| CHEMBL35411 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL34372 | — | Ki | = | 63.0 | nM | 7.20 |