Assay Detail
Binding
CHEMBL674433
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Displacement of [3H]WIN-35 428 binding at dopamine transporter (DAT) in rat caudate putamen
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Caudate-putamen |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel tropane-based irreversible ligands for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.22 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2308105 | — | — | 1 | 8.07 |
| CHEMBL138156 | — | — | 1 | 7.84 |
| CHEMBL3084934 | — | — | 1 | 7.70 |
| CHEMBL3084929 | — | — | 1 | 7.53 |
| CHEMBL138651 | — | — | 1 | 7.50 |
| CHEMBL136566 | — | — | 1 | 7.48 |
| CHEMBL2079586 | — | — | 1 | 7.36 |
| CHEMBL3084932 | — | — | 1 | 6.80 |
| CHEMBL3084930 | — | — | 1 | 6.55 |
| CHEMBL3084933 | — | — | 1 | 6.38 |
| CHEMBL3084931 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2308105 | — | Ki | = | 8.51 | nM | 8.07 |
| CHEMBL138156 | — | Ki | = | 14.5 | nM | 7.84 |
| CHEMBL3084934 | — | Ki | = | 20.2 | nM | 7.70 |
| CHEMBL3084929 | — | Ki | = | 29.7 | nM | 7.53 |
| CHEMBL138651 | — | Ki | = | 31.5 | nM | 7.50 |
| CHEMBL136566 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL2079586 | — | Ki | = | 43.7 | nM | 7.36 |
| CHEMBL3084932 | — | Ki | = | 159.0 | nM | 6.80 |
| CHEMBL3084930 | — | Ki | = | 284.0 | nM | 6.55 |
| CHEMBL3084933 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL3084931 | — | Ki | = | 611.0 | nM | 6.21 |