Assay Detail
Binding
CHEMBL674434
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Displacement of [3H]WIN-35428 from dopamine transporter (DAT)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, dopamine and serotonin transporter binding affinities of novel analogues of meperidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.27 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL326243 | — | — | 1 | 6.90 |
| CHEMBL419744 | — | — | 1 | 5.94 |
| CHEMBL109386 | — | — | 1 | 5.63 |
| CHEMBL113336 | — | — | 1 | 5.57 |
| CHEMBL113479 | — | — | 1 | 5.49 |
| CHEMBL113480 | — | — | 1 | 5.39 |
| CHEMBL110967 | — | — | 1 | 5.08 |
| CHEMBL112817 | — | — | 1 | 4.97 |
| CHEMBL323600 | — | — | 1 | 4.91 |
| CHEMBL324465 | — | — | 1 | 4.80 |
| CHEMBL607 | MEPERIDINE | 4.0 | 1 | 4.75 |
| CHEMBL324886 | — | — | 1 | 4.66 |
| CHEMBL111498 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL326243 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL419744 | — | Ki | = | 1140.0 | nM | 5.94 |
| CHEMBL109386 | — | Ki | = | 2360.0 | nM | 5.63 |
| CHEMBL113336 | — | Ki | = | 2670.0 | nM | 5.57 |
| CHEMBL113479 | — | Ki | = | 3250.0 | nM | 5.49 |
| CHEMBL113480 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL110967 | — | Ki | = | 8340.0 | nM | 5.08 |
| CHEMBL112817 | — | Ki | = | 10700.0 | nM | 4.97 |
| CHEMBL323600 | — | Ki | = | 12400.0 | nM | 4.91 |
| CHEMBL324465 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL607 | MEPERIDINE | Ki | = | 17800.0 | nM | 4.75 |
| CHEMBL324886 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL111498 | — | Ki | = | 41800.0 | nM | 4.38 |