Assay Detail
Binding
CHEMBL674574
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of epidermal growth factor receptor (EGFr) using ATP substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congeners.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.36 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL342929 | — | — | 1 | 5.64 |
| CHEMBL336409 | — | — | 1 | 5.57 |
| CHEMBL137422 | — | — | 1 | 5.51 |
| CHEMBL336174 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL342929 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL336409 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL137422 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL336174 | — | Ki | = | 19400.0 | nM | 4.71 |