Assay Detail
Binding
CHEMBL674642
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Inhibition of EGF-R Tyrosine kinase (TK)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel antiproliferative agents derived from lavendustin A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.26 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319620 | LAVENDUSTIN C | — | 1 | 5.54 |
| CHEMBL103860 | — | — | 1 | 5.48 |
| CHEMBL103552 | LAVENDUSTIN A | — | 1 | 5.39 |
| CHEMBL131653 | — | — | 1 | 4.61 |
| CHEMBL131405 | — | — | 1 | - |
| CHEMBL341459 | — | — | 1 | - |
| CHEMBL129856 | — | — | 1 | - |
| CHEMBL130633 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319620 | LAVENDUSTIN C | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL103860 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL103552 | LAVENDUSTIN A | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL131653 | — | IC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL131405 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL341459 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL129856 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL130633 | — | IC50 | > | 100000.0 | nM | - |