Assay Detail
Binding
CHEMBL674643
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Inhibitory concentration of EGF dependent autophosphorylation of epidermal growth factor receptor kinase
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 67 | 5.03 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76589 | — | — | 1 | 6.90 |
| CHEMBL77803 | — | — | 1 | 6.30 |
| CHEMBL78257 | TYRPHOSTIN 51 | — | 1 | 6.10 |
| CHEMBL80745 | — | — | 1 | 5.92 |
| CHEMBL77030 | TYRPHOSTIN 47 | — | 1 | 5.62 |
| CHEMBL309334 | — | — | 1 | 5.60 |
| CHEMBL310798 | TYRPHOSTIN 25 | — | 1 | 5.52 |
| CHEMBL80155 | — | — | 1 | 5.22 |
| CHEMBL296407 | — | — | 1 | 5.00 |
| CHEMBL309598 | — | — | 1 | 4.87 |
| CHEMBL47986 | ERBSTATIN | — | 1 | 4.85 |
| CHEMBL73820 | — | — | 1 | 4.60 |
| CHEMBL76904 | TYRPHOSTIN 23 | — | 1 | 4.46 |
| CHEMBL76905 | — | — | 1 | 4.43 |
| CHEMBL76985 | — | — | 1 | 4.33 |
| CHEMBL77243 | — | — | 1 | 4.26 |
| CHEMBL309625 | — | — | 1 | 4.22 |
| CHEMBL311119 | — | — | 1 | 4.22 |
| CHEMBL76642 | — | — | 1 | 4.12 |
| CHEMBL77085 | — | — | 1 | 4.02 |
| CHEMBL311564 | — | — | 1 | - |
| CHEMBL307248 | — | — | 1 | - |
| CHEMBL307250 | — | — | 1 | - |
| CHEMBL310958 | — | — | 1 | - |
| CHEMBL78005 | — | — | 1 | - |
| CHEMBL77595 | — | — | 1 | - |
| CHEMBL77778 | — | — | 1 | - |
| CHEMBL57712 | — | — | 1 | - |
| CHEMBL77869 | — | — | 1 | - |
| CHEMBL76082 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76589 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL77803 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL78257 | TYRPHOSTIN 51 | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL80745 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL77030 | TYRPHOSTIN 47 | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL309334 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL310798 | TYRPHOSTIN 25 | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL80155 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL296407 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL309598 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL47986 | ERBSTATIN | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL73820 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL76904 | TYRPHOSTIN 23 | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL76905 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL76985 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL77243 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL311119 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL309625 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL76642 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL77085 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL310400 | — | IC50 | = | 375000.0 | nM | - |
| CHEMBL76602 | alpha-CYANO-4-HYDROXYCINNAMIC ACID | IC50 | = | 165000.0 | nM | - |
| CHEMBL79064 | — | IC50 | = | 230000.0 | nM | - |
| CHEMBL75718 | — | IC50 | = | 2400000.0 | nM | - |
| CHEMBL77298 | — | IC50 | = | 153000.0 | nM | - |
| CHEMBL77280 | — | IC50 | > | 1250000.0 | nM | - |
| CHEMBL66879 | COUMARIC ACID | IC50 | = | 3000000.0 | nM | - |
| CHEMBL76979 | — | IC50 | = | 264000.0 | nM | - |
| CHEMBL77724 | — | IC50 | > | 1250000.0 | nM | - |
| CHEMBL420385 | — | IC50 | > | 625000.0 | nM | - |
| CHEMBL1009 | LEVODOPA | IC50 | = | 900000.0 | nM | - |
| CHEMBL77825 | — | IC50 | = | 600000.0 | nM | - |
| CHEMBL421877 | — | IC50 | = | 850000.0 | nM | - |
| CHEMBL309866 | — | IC50 | = | 1300000.0 | nM | - |
| CHEMBL77381 | — | IC50 | = | 1360000.0 | nM | - |
| CHEMBL307179 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL308133 | — | IC50 | = | 1500000.0 | nM | - |
| CHEMBL78150 | TYRPHOSTIN A9 | IC50 | = | 460000.0 | nM | - |
| CHEMBL310514 | — | IC50 | = | 260000.0 | nM | - |
| CHEMBL305695 | — | IC50 | = | 560000.0 | nM | - |
| CHEMBL76082 | — | IC50 | = | 560000.0 | nM | - |
| CHEMBL77869 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL57712 | — | IC50 | = | 1300000.0 | nM | - |
| CHEMBL77778 | — | IC50 | = | 450000.0 | nM | - |
| CHEMBL77595 | — | IC50 | = | 850000.0 | nM | - |
| CHEMBL78005 | — | IC50 | = | 350000.0 | nM | - |
| CHEMBL310958 | — | IC50 | = | 225000.0 | nM | - |
| CHEMBL307250 | — | IC50 | = | 325000.0 | nM | - |
| CHEMBL307248 | — | IC50 | = | 640000.0 | nM | - |
| CHEMBL311564 | — | IC50 | = | 450000.0 | nM | - |