Assay Detail
Binding
CHEMBL674693
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Inhibition of Epidermal growth factor receptor (EGF-R) tyrosine kinase activity
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
7-Alkyl- and 7-cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.06 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169390 | — | — | 1 | 7.10 |
| CHEMBL169570 | — | — | 1 | 6.60 |
| CHEMBL355330 | — | — | 1 | 6.52 |
| CHEMBL354310 | — | — | 1 | 6.48 |
| CHEMBL352801 | — | — | 1 | 6.38 |
| CHEMBL171311 | — | — | 1 | 6.36 |
| CHEMBL355191 | — | — | 1 | 6.35 |
| CHEMBL168382 | — | — | 1 | 6.34 |
| CHEMBL168550 | — | — | 1 | 6.31 |
| CHEMBL352954 | — | — | 1 | 6.30 |
| CHEMBL170724 | — | — | 1 | 6.24 |
| CHEMBL166765 | — | — | 1 | 6.22 |
| CHEMBL166766 | — | — | 1 | 6.14 |
| CHEMBL168285 | — | — | 1 | 6.10 |
| CHEMBL168266 | — | — | 1 | 5.55 |
| CHEMBL169467 | — | — | 1 | 5.47 |
| CHEMBL168555 | — | — | 1 | 5.01 |
| CHEMBL170438 | — | — | 1 | 4.88 |
| CHEMBL171256 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169390 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL169570 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL355330 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL354310 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL352801 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL171311 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL355191 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL168382 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL168550 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL352954 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL170724 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL166765 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL166766 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL168285 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL168266 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL169467 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL168555 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL170438 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL171256 | — | IC50 | = | 14400.0 | nM | 4.84 |