Assay Detail
Binding
CHEMBL674820
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested by chromogenic assay for the inhibition of serine proteases like Porcine Elastase
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Chymotrypsin-like elastase family member 2A (CHEMBL2407) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
N-[2,2-dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: structural requirements for potent inhibition of alpha-chymotrypsin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.04 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108294 | — | — | 3 | 9.15 |
| CHEMBL111705 | — | — | 1 | 6.70 |
| CHEMBL320132 | — | — | 1 | 6.57 |
| CHEMBL111745 | — | — | 1 | 5.57 |
| CHEMBL110995 | — | — | 1 | 5.38 |
| CHEMBL109601 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108294 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL108294 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL108294 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL111705 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL320132 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL111745 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL110995 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL109601 | — | IC50 | = | 710000.0 | nM | - |