Assay Detail
Functional
CHEMBL674899
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cyprinus carpio |
| Tissue | Retina |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 34 | 7.48 | 8.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415080 | — | — | 1 | 8.99 |
| CHEMBL315750 | — | — | 1 | 8.89 |
| CHEMBL86931 | — | — | 1 | 8.71 |
| CHEMBL313304 | — | — | 1 | 8.70 |
| CHEMBL315468 | — | — | 1 | 8.68 |
| CHEMBL314459 | — | — | 1 | 8.51 |
| CHEMBL87734 | — | — | 1 | 8.46 |
| CHEMBL313530 | — | — | 1 | 8.29 |
| CHEMBL84983 | — | — | 1 | 8.28 |
| CHEMBL85689 | — | — | 1 | 8.24 |
| CHEMBL431220 | — | — | 1 | 8.20 |
| CHEMBL315005 | — | — | 1 | 8.19 |
| CHEMBL85409 | — | — | 1 | 8.17 |
| CHEMBL420788 | — | — | 1 | 7.90 |
| CHEMBL420972 | — | — | 1 | 7.87 |
| CHEMBL82899 | — | — | 1 | 7.79 |
| CHEMBL86576 | — | — | 1 | 7.62 |
| CHEMBL87910 | — | — | 1 | 7.46 |
| CHEMBL315535 | — | — | 1 | 7.42 |
| CHEMBL419680 | — | — | 1 | 7.33 |
| CHEMBL315849 | — | — | 1 | 7.17 |
| CHEMBL420604 | — | — | 1 | 7.16 |
| CHEMBL86325 | — | — | 1 | 7.05 |
| CHEMBL87172 | — | — | 1 | 7.00 |
| CHEMBL86669 | — | — | 1 | 6.91 |
| CHEMBL2115213 | — | — | 1 | 6.85 |
| CHEMBL2114209 | — | — | 1 | 6.63 |
| CHEMBL87897 | — | — | 1 | 6.62 |
| CHEMBL24077 | (R)-SKF-38393 | — | 1 | 6.41 |
| CHEMBL87958 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415080 | — | EC50 | = | 1.02 | nM | 8.99 |
| CHEMBL315750 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL86931 | — | EC50 | = | 1.95 | nM | 8.71 |
| CHEMBL313304 | — | EC50 | = | 2.02 | nM | 8.70 |
| CHEMBL315468 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL314459 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL87734 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL313530 | — | EC50 | = | 5.1 | nM | 8.29 |
| CHEMBL84983 | — | EC50 | = | 5.2 | nM | 8.28 |
| CHEMBL85689 | — | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL431220 | — | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL315005 | — | EC50 | = | 6.4 | nM | 8.19 |
| CHEMBL85409 | — | EC50 | = | 6.7 | nM | 8.17 |
| CHEMBL420788 | — | EC50 | = | 12.5 | nM | 7.90 |
| CHEMBL420972 | — | EC50 | = | 13.6 | nM | 7.87 |
| CHEMBL82899 | — | EC50 | = | 16.4 | nM | 7.79 |
| CHEMBL86576 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL87910 | — | EC50 | = | 34.4 | nM | 7.46 |
| CHEMBL315535 | — | EC50 | = | 37.6 | nM | 7.42 |
| CHEMBL419680 | — | EC50 | = | 46.5 | nM | 7.33 |
| CHEMBL315849 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL420604 | — | EC50 | = | 68.7 | nM | 7.16 |
| CHEMBL86325 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL87172 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL86669 | — | EC50 | = | 124.0 | nM | 6.91 |
| CHEMBL2115213 | — | EC50 | = | 142.0 | nM | 6.85 |
| CHEMBL2114209 | — | EC50 | = | 232.0 | nM | 6.63 |
| CHEMBL87897 | — | EC50 | = | 237.0 | nM | 6.62 |
| CHEMBL24077 | (R)-SKF-38393 | EC50 | = | 386.0 | nM | 6.41 |
| CHEMBL87958 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL84557 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL85552 | — | EC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL315516 | — | EC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL83080 | — | EC50 | = | 8580.0 | nM | 5.07 |