Assay Detail
Functional
CHEMBL674900
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Formation of cAMP on Dopamine receptor D1 in vitro in carp retina
10
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cyprinus carpio |
| Tissue | Retina |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
(1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.04 | 8.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86931 | — | — | 4 | 8.71 |
| CHEMBL286080 | SKF-38393 | — | 2 | 6.41 |
| CHEMBL99361 | — | — | 1 | 6.31 |
| CHEMBL542683 | — | — | 1 | 6.31 |
| CHEMBL83080 | — | — | 2 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86931 | — | EC50 | = | 1.95 | nM | 8.71 |
| CHEMBL86931 | — | EC50 | = | 1.95 | nM | 8.71 |
| CHEMBL86931 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL86931 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL286080 | SKF-38393 | EC50 | = | 386.0 | nM | 6.41 |
| CHEMBL286080 | SKF-38393 | EC50 | = | 386.0 | nM | 6.41 |
| CHEMBL99361 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL542683 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL83080 | — | EC50 | = | 8577.0 | nM | 5.07 |
| CHEMBL83080 | — | EC50 | = | 8577.0 | nM | 5.07 |