Assay Detail
Functional
CHEMBL674932
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.82 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314459 | — | — | 1 | 8.77 |
| CHEMBL315468 | — | — | 1 | 8.15 |
| CHEMBL313530 | — | — | 1 | 8.08 |
| CHEMBL84983 | — | — | 1 | 7.72 |
| CHEMBL420972 | — | — | 1 | 7.63 |
| CHEMBL419680 | — | — | 1 | 7.52 |
| CHEMBL86576 | — | — | 1 | 7.40 |
| CHEMBL82899 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314459 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL315468 | — | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL313530 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL84983 | — | EC50 | = | 18.9 | nM | 7.72 |
| CHEMBL420972 | — | EC50 | = | 23.4 | nM | 7.63 |
| CHEMBL419680 | — | EC50 | = | 30.3 | nM | 7.52 |
| CHEMBL86576 | — | EC50 | = | 39.8 | nM | 7.40 |
| CHEMBL82899 | — | EC50 | = | 52.3 | nM | 7.28 |