Assay Detail
Functional
CHEMBL674935
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Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dopamine agonists related to 3-allyl-6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzaz epi ne-7, 8-diol. 6-Position modifications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.09 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130795 | — | — | 1 | 7.82 |
| CHEMBL552611 | — | — | 1 | 7.60 |
| CHEMBL131313 | — | — | 1 | 7.30 |
| CHEMBL129634 | — | — | 1 | 7.00 |
| CHEMBL540575 | — | — | 1 | 6.40 |
| CHEMBL538785 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130795 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL552611 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL131313 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL129634 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL540575 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL538785 | — | EC50 | = | 400.0 | nM | 6.40 |