Assay Detail
Binding
CHEMBL674993
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity to displace [3H]spiperone from cloned human Dopamine receptor D3 (hD3) stably expressed in HEK393 cell lines
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK393 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.46 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93432 | — | — | 1 | 7.82 |
| CHEMBL90005 | — | — | 1 | 7.42 |
| CHEMBL328739 | — | — | 1 | 6.85 |
| CHEMBL93969 | — | — | 1 | 6.75 |
| CHEMBL263162 | — | — | 1 | 6.66 |
| CHEMBL89971 | — | — | 1 | 6.66 |
| CHEMBL91162 | — | — | 1 | 6.62 |
| CHEMBL94283 | — | — | 1 | 6.60 |
| CHEMBL92859 | — | — | 1 | 6.50 |
| CHEMBL450021 | — | — | 1 | 6.44 |
| CHEMBL94023 | — | — | 1 | 6.42 |
| CHEMBL91621 | — | — | 1 | 6.16 |
| CHEMBL444309 | — | — | 1 | 6.11 |
| CHEMBL91272 | — | — | 1 | 6.02 |
| CHEMBL316125 | — | — | 1 | 5.96 |
| CHEMBL91553 | — | — | 1 | 5.92 |
| CHEMBL327176 | — | — | 1 | 5.72 |
| CHEMBL328667 | — | — | 1 | 5.70 |
| CHEMBL327310 | — | — | 1 | - |
| CHEMBL93832 | — | — | 1 | - |
| CHEMBL91229 | — | — | 1 | - |
| CHEMBL91155 | — | — | 1 | - |
| CHEMBL93970 | — | — | 1 | - |
| CHEMBL431095 | — | — | 1 | - |
| CHEMBL90711 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93432 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL90005 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL328739 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL93969 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL263162 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL89971 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL91162 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL94283 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL92859 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL450021 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL94023 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL91621 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL444309 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL91272 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL316125 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL91553 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL327176 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL328667 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL327310 | — | Ki | > | 4400.0 | nM | - |
| CHEMBL93832 | — | Ki | > | 4700.0 | nM | - |
| CHEMBL91229 | — | Ki | > | 3200.0 | nM | - |
| CHEMBL91155 | — | Ki | > | 3900.0 | nM | - |
| CHEMBL93970 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL431095 | — | Ki | > | 4800.0 | nM | - |
| CHEMBL90711 | — | Ki | > | 4400.0 | nM | - |