Assay Detail
Binding
CHEMBL674997
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Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDAT
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 18 | 5.82 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL809 | SERTRALINE | 4.0 | 1 | 7.60 |
| CHEMBL539050 | — | — | 1 | 7.16 |
| CHEMBL539564 | — | — | 1 | 6.85 |
| CHEMBL306700 | VILOXAZINE | 4.0 | 1 | 6.81 |
| CHEMBL543925 | — | — | 1 | 6.47 |
| CHEMBL539054 | — | — | 1 | 6.47 |
| CHEMBL623 | NEFAZODONE | 4.0 | 1 | 6.44 |
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 6.31 |
| CHEMBL641 | ATOMOXETINE | 4.0 | 1 | 5.97 |
| CHEMBL538053 | — | — | 1 | 5.46 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 5.44 |
| CHEMBL540333 | — | — | 1 | 5.37 |
| CHEMBL555280 | — | — | 1 | 5.14 |
| CHEMBL637 | VENLAFAXINE | 4.0 | 1 | 5.03 |
| CHEMBL542501 | — | — | 1 | 4.67 |
| CHEMBL542746 | — | — | 1 | 4.62 |
| CHEMBL545557 | — | — | 1 | 4.57 |
| CHEMBL544633 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL809 | SERTRALINE | Kd | = | 25.0 | nM | 7.60 |
| CHEMBL539050 | — | Kd | = | 70.0 | nM | 7.16 |
| CHEMBL539564 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL306700 | VILOXAZINE | Kd | = | 155.0 | nM | 6.81 |
| CHEMBL543925 | — | Kd | = | 340.0 | nM | 6.47 |
| CHEMBL539054 | — | Kd | = | 340.0 | nM | 6.47 |
| CHEMBL623 | NEFAZODONE | Kd | = | 360.0 | nM | 6.44 |
| CHEMBL490 | PAROXETINE | Kd | = | 490.0 | nM | 6.31 |
| CHEMBL641 | ATOMOXETINE | Kd | = | 1080.0 | nM | 5.97 |
| CHEMBL538053 | — | Kd | = | 3500.0 | nM | 5.46 |
| CHEMBL41 | FLUOXETINE | Kd | = | 3600.0 | nM | 5.44 |
| CHEMBL540333 | — | Kd | = | 4310.0 | nM | 5.37 |
| CHEMBL555280 | — | Kd | = | 7260.0 | nM | 5.14 |
| CHEMBL637 | VENLAFAXINE | Kd | = | 9300.0 | nM | 5.03 |
| CHEMBL542501 | — | Kd | = | 21400.0 | nM | 4.67 |
| CHEMBL542746 | — | Kd | = | 24000.0 | nM | 4.62 |
| CHEMBL545557 | — | Kd | = | 27000.0 | nM | 4.57 |
| CHEMBL544633 | — | Kd | = | 42000.0 | nM | 4.38 |