Compound Detail
CHEMBL306700
VILOXAZINE 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL306700 |
| Name | VILOXAZINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | YWPHCCPCQOJSGZ-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
7
Targets
9
Activities
3
Assay Types
3
PK Parameters
20
Publications
3
Known Names
1
Indications
Molecular Properties
237.3
MW (Da)
1.45
ALogP
4
HBA
1
HBD
39.7
PSA (Ų)
0.84
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2021 |
| Availability | Prescription |
| Chirality | Racemic |
Indications
Depressive Disorder
ATC Classification
N06AX09
viloxazine
Level 1: NERVOUS SYSTEM
Level 2: PSYCHOANALEPTICS
Activity Summary
IC50 3 meas. best 6.66
Kd 3 meas. best 6.81
Ki 3 meas. best 6.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium-dependent noradrenaline transporter CHEMBL222 | Kd | 6.81 | 6.81 | 155.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL238 | Kd | 6.81 | 6.81 | 155.0 | 1 |
| Norepinephrine transporter CHEMBL304 | Ki | 6.77 | 6.77 | 170.0 | 1 |
| Sus scrofa CHEMBL613488 | IC50 | 6.66 | 5.26 | 220.0 | 3 |
| Sodium-dependent serotonin transporter CHEMBL313 | Ki | 4.78 | 4.78 | 16500.0 | 1 |
| Sodium-dependent serotonin transporter CHEMBL228 | Kd | 4.76 | 4.76 | 17300.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL338 | Ki | 4.32 | 4.32 | 48000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 2.1 | mL.min-1.kg-1 | Homo sapiens |
| MRT | 5.8 | hr | Homo sapiens |
| T1/2 | 4.1 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine