Assay Detail
Binding
CHEMBL792305
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Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomes
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.70 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL641 | ATOMOXETINE | 4.0 | 1 | 9.15 |
| CHEMBL539564 | — | — | 1 | 8.11 |
| CHEMBL543925 | — | — | 1 | 8.00 |
| CHEMBL539050 | — | — | 1 | 7.82 |
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 7.48 |
| CHEMBL545557 | — | — | 1 | 7.36 |
| CHEMBL637 | VENLAFAXINE | 4.0 | 1 | 6.86 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 6.84 |
| CHEMBL306700 | VILOXAZINE | 4.0 | 1 | 6.77 |
| CHEMBL809 | SERTRALINE | 4.0 | 1 | 6.66 |
| CHEMBL538053 | — | — | 1 | 6.66 |
| CHEMBL540333 | — | — | 1 | 6.48 |
| CHEMBL623 | NEFAZODONE | 4.0 | 1 | 6.24 |
| CHEMBL542501 | — | — | 1 | 6.08 |
| CHEMBL556025 | — | — | 1 | 6.00 |
| CHEMBL555280 | — | — | 1 | 5.42 |
| CHEMBL542746 | — | — | 1 | 5.24 |
| CHEMBL539054 | — | — | 1 | 5.07 |
| CHEMBL544633 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL641 | ATOMOXETINE | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL539564 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL543925 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL539050 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL490 | PAROXETINE | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL545557 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL637 | VENLAFAXINE | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL41 | FLUOXETINE | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL306700 | VILOXAZINE | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL809 | SERTRALINE | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL538053 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL540333 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL623 | NEFAZODONE | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL542501 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL556025 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL555280 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL542746 | — | Ki | = | 5780.0 | nM | 5.24 |
| CHEMBL539054 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL544633 | — | Ki | = | 8500.0 | nM | 5.07 |