Assay Detail
Functional
CHEMBL756962
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Tested for in vitro reuptake inhibition of [3H]norepinephrine in pig occipital synaptosomes.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
3-[(2-ethoxyphenoxy)methyl]piperidine derivatives. Synthesis and antidepressant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.65 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72 | DESIPRAMINE | 4.0 | 1 | 8.49 |
| CHEMBL306700 | VILOXAZINE | 4.0 | 1 | 6.66 |
| CHEMBL553797 | — | — | 1 | 6.18 |
| CHEMBL73320 | — | — | 1 | 6.01 |
| CHEMBL70457 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72 | DESIPRAMINE | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL306700 | VILOXAZINE | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL553797 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL73320 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL70457 | — | IC50 | = | 1300.0 | nM | 5.89 |