Assay Detail
Binding
CHEMBL675006
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]BTCP binding to the dopamine transporter.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.02 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 8.40 |
| CHEMBL279556 | — | — | 1 | 8.30 |
| CHEMBL781 | MAZINDOL | 4.0 | 1 | 7.89 |
| CHEMBL273575 | NOMIFENSINE | 4.0 | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL279556 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL781 | MAZINDOL | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL273575 | NOMIFENSINE | IC50 | = | 34.0 | nM | 7.47 |