Assay Detail
Binding
CHEMBL675011
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Potency for the inhibition of [3H]WIN-35428 binding to the dopamine transporter
26
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.04 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300226 | — | — | 1 | 9.00 |
| CHEMBL2373962 | — | — | 1 | 8.70 |
| CHEMBL3143431 | — | — | 2 | 8.10 |
| CHEMBL1790051 | — | — | 2 | 7.64 |
| CHEMBL2310855 | — | — | 1 | 7.19 |
| CHEMBL176297 | — | — | 1 | 6.95 |
| CHEMBL120901 | — | — | 8 | 6.89 |
| CHEMBL174864 | — | — | 1 | 6.57 |
| CHEMBL172482 | — | — | 1 | 6.52 |
| CHEMBL426954 | — | — | 1 | 5.98 |
| CHEMBL175375 | — | — | 1 | 5.91 |
| CHEMBL362395 | — | — | 1 | 5.84 |
| CHEMBL369439 | — | — | 1 | 5.50 |
| CHEMBL176566 | — | — | 1 | 5.08 |
| CHEMBL174532 | — | — | 1 | 4.97 |
| CHEMBL1947052 | — | — | 1 | 4.67 |
| CHEMBL284394 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300226 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2373962 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3143431 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1790051 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2310855 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL176297 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL120901 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL174864 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL172482 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL1790051 | — | IC50 | = | 561.0 | nM | 6.25 |
| CHEMBL3143431 | — | IC50 | = | 748.0 | nM | 6.13 |
| CHEMBL426954 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL175375 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL362395 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL369439 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL120901 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL176566 | — | IC50 | = | 8250.0 | nM | 5.08 |
| CHEMBL120901 | — | IC50 | = | 9820.0 | nM | 5.01 |
| CHEMBL174532 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL120901 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL120901 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL1947052 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL120901 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL120901 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL120901 | — | IC50 | = | 67700.0 | nM | 4.17 |
| CHEMBL284394 | — | IC50 | = | 195000.0 | nM | - |