Assay Detail
Binding
CHEMBL675086
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Binding Affinity was tested on High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially the D(3) subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.66 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL165171 | — | — | 1 | 5.66 |
| CHEMBL163087 | — | — | 1 | - |
| CHEMBL162762 | — | — | 1 | - |
| CHEMBL164950 | — | — | 1 | - |
| CHEMBL166325 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL165171 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL163087 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL162762 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL164950 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL166325 | — | Ki | > | 20000.0 | nM | - |