Assay Detail
Binding
CHEMBL675168
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Inhibition of [3H]mazindol binding to the dopamine transporter.
14
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.54 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2373962 | — | — | 1 | 8.30 |
| CHEMBL1790051 | — | — | 1 | 6.92 |
| CHEMBL368314 | — | — | 1 | 6.44 |
| CHEMBL172482 | — | — | 1 | 5.92 |
| CHEMBL175375 | — | — | 1 | 5.52 |
| CHEMBL176566 | — | — | 1 | 5.35 |
| CHEMBL174532 | — | — | 1 | 4.70 |
| CHEMBL175229 | — | — | 2 | 4.21 |
| CHEMBL120901 | — | — | 3 | 4.01 |
| CHEMBL176442 | — | — | 1 | - |
| CHEMBL284394 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2373962 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1790051 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL368314 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL172482 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL175375 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL176566 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL174532 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL175229 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL175229 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL120901 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL176442 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL120901 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL120901 | — | IC50 | = | 116000.0 | nM | - |
| CHEMBL284394 | — | IC50 | = | 392000.0 | nM | - |