Assay Detail
Binding
CHEMBL675226
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The compound was tested for its affinity at the rat striatal dopamine transporter by the displacement of [3H]WIN-35428
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Further evidence for a dopamine reuptake pharmacophore. The effect of N-methylation on Threo-methylphenidate and its analogs
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.04 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19607 | — | — | 1 | 8.29 |
| CHEMBL1253339 | — | — | 1 | 7.67 |
| CHEMBL283772 | — | — | 1 | 7.48 |
| CHEMBL827 | DEXMETHYLPHENIDATE | 4.0 | 1 | 7.08 |
| CHEMBL1253698 | — | — | 1 | 7.01 |
| CHEMBL19686 | — | — | 1 | 6.97 |
| CHEMBL20110 | — | — | 1 | 6.86 |
| CHEMBL19869 | — | — | 1 | 6.79 |
| CHEMBL20099 | — | — | 1 | 6.30 |
| CHEMBL19891 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19607 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL1253339 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL283772 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL827 | DEXMETHYLPHENIDATE | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1253698 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL19686 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL20110 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL19869 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL20099 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL19891 | — | IC50 | = | 1220.0 | nM | 5.91 |