Assay Detail
Binding
CHEMBL675242
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibit of epidermal growth factor receptor (EGFR)
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.42 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367625 | — | — | 2 | 5.70 |
| CHEMBL368278 | — | — | 1 | 5.28 |
| CHEMBL534909 | — | — | 1 | - |
| CHEMBL173647 | — | — | 1 | - |
| CHEMBL557975 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367625 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL367625 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL368278 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL534909 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL173647 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL557975 | — | IC50 | > | 10000.0 | nM | - |