Assay Detail
Binding
CHEMBL675384
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Inhibition of Grb-SH2 domain binding to phosphorylated carboxy-terminal intracellular domain of epidermal growth factor receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Growth factor receptor-bound protein 2 (CHEMBL3663) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Highly potent inhibitors of the Grb2-SH2 domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.20 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL73003 | — | — | 1 | 9.52 |
| CHEMBL72036 | — | — | 1 | 9.40 |
| CHEMBL72694 | — | — | 1 | 9.05 |
| CHEMBL431982 | — | — | 1 | 8.92 |
| CHEMBL72525 | — | — | 1 | 8.47 |
| CHEMBL72996 | — | — | 1 | 8.04 |
| CHEMBL70852 | — | — | 1 | 7.85 |
| CHEMBL72437 | — | — | 1 | 7.83 |
| CHEMBL431381 | — | — | 1 | 7.23 |
| CHEMBL72114 | — | — | 1 | 7.09 |
| CHEMBL71034 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL73003 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL72036 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL72694 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL431982 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL72525 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL72996 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL70852 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL72437 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL431381 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL72114 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL71034 | — | IC50 | = | 155.0 | nM | 6.81 |