Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL675386

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of the epidermal growth factor receptor.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Epidermal growth factor receptor (CHEMBL203)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives
Zimmermann J, Buchdunger E, Mett H, Meyer T, Lydon NB
Bioorg Med Chem Lett (1997) 7 : 187 -192
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 32 4.67 6.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL293991 1 6.28
CHEMBL55379 1 5.75
CHEMBL58436 1 5.15
CHEMBL59099 1 4.35
CHEMBL57553 1 4.30
CHEMBL20926 1 4.19
CHEMBL57690 1 4.00
CHEMBL56081 1 4.00
CHEMBL299707 1 4.00
CHEMBL59036 1 -
CHEMBL56669 1 -
CHEMBL55683 1 -
CHEMBL418279 1 -
CHEMBL423288 1 -
CHEMBL20252 1 -
CHEMBL277931 1 -
CHEMBL300817 1 -
CHEMBL21162 1 -
CHEMBL57581 1 -
CHEMBL60816 1 -
CHEMBL56904 1 -
CHEMBL58580 1 -
CHEMBL418270 1 -
CHEMBL58142 1 -
CHEMBL418010 1 -
CHEMBL55592 1 -
CHEMBL56359 1 -
CHEMBL291963 1 -
CHEMBL278103 1 -
CHEMBL55662 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL293991 IC50 = 530.0 nM 6.28
CHEMBL55379 IC50 = 1800.0 nM 5.75
CHEMBL58436 IC50 = 7100.0 nM 5.15
CHEMBL59099 IC50 = 45000.0 nM 4.35
CHEMBL57553 IC50 = 50000.0 nM 4.30
CHEMBL20926 IC50 = 65000.0 nM 4.19
CHEMBL57690 IC50 = 100000.0 nM 4.00
CHEMBL56081 IC50 = 100000.0 nM 4.00
CHEMBL299707 IC50 = 100000.0 nM 4.00
CHEMBL56669 IC50 > 100000.0 nM -
CHEMBL20867 IC50 > 100000.0 nM -
CHEMBL55683 IC50 > 100000.0 nM -
CHEMBL418279 IC50 > 50000.0 nM -
CHEMBL423288 IC50 > 100000.0 nM -
CHEMBL20252 IC50 > 100000.0 nM -
CHEMBL277931 IC50 > 50000.0 nM -
CHEMBL300817 IC50 > 100000.0 nM -
CHEMBL21162 IC50 > 100000.0 nM -
CHEMBL57581 IC50 > 100000.0 nM -
CHEMBL941 IMATINIB IC50 > 100000.0 nM -
CHEMBL59036 IC50 > 100000.0 nM -
CHEMBL60816 IC50 > 100000.0 nM -
CHEMBL56904 IC50 > 100000.0 nM -
CHEMBL58580 IC50 > 100000.0 nM -
CHEMBL418270 IC50 > 100000.0 nM -
CHEMBL58142 IC50 > 100000.0 nM -
CHEMBL418010 IC50 > 100000.0 nM -
CHEMBL55592 IC50 > 100000.0 nM -
CHEMBL56359 IC50 > 50000.0 nM -
CHEMBL291963 IC50 > 100000.0 nM -
CHEMBL278103 IC50 > 100000.0 nM -
CHEMBL55662 IC50 > 100000.0 nM -