Assay Detail
Binding
CHEMBL675441
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In vitro inhibition of human Endothelin converting Enzyme-1 activity
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent thiol-based inhibitors of endothelin converting enzyme-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.01 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293024 | — | — | 1 | 7.96 |
| CHEMBL292748 | — | — | 1 | 7.96 |
| CHEMBL61269 | — | — | 1 | 7.72 |
| CHEMBL61410 | — | — | 1 | 7.40 |
| CHEMBL292733 | — | — | 1 | 7.27 |
| CHEMBL64081 | — | — | 1 | 7.11 |
| CHEMBL2115491 | — | — | 1 | 7.01 |
| CHEMBL3351079 | — | — | 1 | 6.92 |
| CHEMBL63132 | — | — | 1 | 6.85 |
| CHEMBL304408 | — | — | 1 | 6.77 |
| CHEMBL292044 | — | — | 1 | 6.70 |
| CHEMBL303775 | — | — | 1 | 6.68 |
| CHEMBL303570 | — | — | 1 | 6.62 |
| CHEMBL59775 | — | — | 1 | 6.55 |
| CHEMBL2114468 | — | — | 1 | 6.39 |
| CHEMBL60679 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293024 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL292748 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL61269 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL61410 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL292733 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL64081 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2115491 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL3351079 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL63132 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL304408 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL292044 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL303775 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL303570 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL59775 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2114468 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL60679 | — | IC50 | = | 510.0 | nM | 6.29 |