Assay Detail
Binding
CHEMBL675445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against Endothelin receptor from rat heart ventricle
31
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Expert |
Publication
Structure-activity relationships of C-terminal endothelin hexapeptide antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.66 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313760 | — | — | 1 | 7.60 |
| CHEMBL1788127 | — | — | 1 | 7.40 |
| CHEMBL313382 | — | — | 1 | 6.89 |
| CHEMBL313984 | — | — | 1 | 6.48 |
| CHEMBL327350 | — | — | 1 | 6.42 |
| CHEMBL85341 | — | — | 1 | 6.40 |
| CHEMBL406279 | — | — | 1 | 6.38 |
| CHEMBL2370070 | — | — | 1 | 6.17 |
| CHEMBL86814 | — | — | 1 | 6.13 |
| CHEMBL313056 | — | — | 1 | 6.13 |
| CHEMBL315047 | — | — | 1 | 6.00 |
| CHEMBL87243 | — | — | 1 | 5.79 |
| CHEMBL315658 | — | — | 1 | 5.67 |
| CHEMBL315780 | — | — | 1 | 5.42 |
| CHEMBL289687 | — | — | 2 | 5.39 |
| CHEMBL438194 | — | — | 1 | 5.36 |
| CHEMBL262166 | — | — | 1 | 5.28 |
| CHEMBL86737 | — | — | 1 | 5.17 |
| CHEMBL431874 | — | — | 1 | 5.05 |
| CHEMBL431218 | — | — | 1 | 4.92 |
| CHEMBL315328 | — | — | 1 | 4.91 |
| CHEMBL2370061 | — | — | 1 | 4.77 |
| CHEMBL87724 | — | — | 1 | 4.61 |
| CHEMBL2370073 | — | — | 1 | 4.43 |
| CHEMBL2114215 | — | — | 1 | 4.41 |
| CHEMBL432091 | — | — | 1 | 4.24 |
| CHEMBL3350293 | — | — | 1 | - |
| CHEMBL2369145 | — | — | 1 | - |
| CHEMBL313122 | — | — | 1 | - |
| CHEMBL314239 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313760 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1788127 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL313382 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL313984 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL327350 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL85341 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL406279 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2370070 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL86814 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL313056 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL315047 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL87243 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL315658 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL315780 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL289687 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL438194 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL289687 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL262166 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL86737 | — | IC50 | = | 6830.0 | nM | 5.17 |
| CHEMBL431874 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL431218 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL315328 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL2370061 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL87724 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL2370073 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL2114215 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL432091 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL3350293 | — | IC50 | = | 169000.0 | nM | - |
| CHEMBL2369145 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL313122 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL314239 | — | IC50 | > | 50000.0 | nM | - |