Assay Detail
Binding
CHEMBL675446
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition constant for the displacement of specific binding of [125I]-ET (Kd=2 nM) bound to rat pituitary membrane
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Pituitary gland |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Structure-activity studies of reduced-size gonadotropin-releasing hormone agonists derived from the sequence of an endothelin antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.47 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317064 | — | — | 1 | 6.92 |
| CHEMBL327528 | — | — | 1 | 5.22 |
| CHEMBL329946 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317064 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL327528 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL329946 | — | Ki | = | 55000.0 | nM | 4.26 |