Assay Detail
Functional
CHEMBL675450
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pA2 value towards endothelin receptor A was determined as functional ETA antagonism
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Endothelin antagonists: evaluation of 2,1,3-benzothiadiazole as a methylendioxyphenyl bioisoster.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.87 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48907 | — | — | 1 | 8.50 |
| CHEMBL25438 | PD-156707 SODIUM | — | 1 | 7.60 |
| CHEMBL303902 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48907 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL25438 | PD-156707 SODIUM | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL303902 | — | Kd | = | 31.62 | nM | 7.50 |