Assay Detail
Functional
CHEMBL675643
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Binding to the sequence 5'-ACAATTAA-3', a site proximal to the delta70 RNA polymerase subunit binding site within the Escherichia coli Trc promoter.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
DNA binding ligands with excellent antibiotic potency against drug-resistant gram-positive bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 20 | 8.65 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405688 | — | — | 1 | 9.54 |
| CHEMBL88042 | — | — | 1 | 9.43 |
| CHEMBL315278 | — | — | 1 | 9.37 |
| CHEMBL86476 | — | — | 1 | 9.28 |
| CHEMBL87605 | — | — | 1 | 9.23 |
| CHEMBL313349 | — | — | 1 | 9.08 |
| CHEMBL405980 | — | — | 1 | 9.00 |
| CHEMBL424431 | — | — | 1 | 8.99 |
| CHEMBL312991 | — | — | 1 | 8.98 |
| CHEMBL445849 | — | — | 1 | 8.92 |
| CHEMBL86328 | — | — | 1 | 8.89 |
| CHEMBL86430 | — | — | 1 | 8.87 |
| CHEMBL315604 | — | — | 1 | 8.76 |
| CHEMBL86848 | — | — | 1 | 8.70 |
| CHEMBL263970 | — | — | 1 | 8.40 |
| CHEMBL313445 | — | — | 1 | 8.36 |
| CHEMBL315277 | — | — | 1 | 8.04 |
| CHEMBL87808 | — | — | 1 | 7.49 |
| CHEMBL66534 | — | — | 1 | 7.08 |
| CHEMBL315344 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405688 | — | Kd | = | 0.29 | nM | 9.54 |
| CHEMBL88042 | — | Kd | = | 0.37 | nM | 9.43 |
| CHEMBL315278 | — | Kd | = | 0.43 | nM | 9.37 |
| CHEMBL86476 | — | Kd | = | 0.53 | nM | 9.28 |
| CHEMBL87605 | — | Kd | = | 0.59 | nM | 9.23 |
| CHEMBL313349 | — | Kd | = | 0.83 | nM | 9.08 |
| CHEMBL405980 | — | Kd | = | 1.01 | nM | 9.00 |
| CHEMBL424431 | — | Kd | = | 1.03 | nM | 8.99 |
| CHEMBL312991 | — | Kd | = | 1.04 | nM | 8.98 |
| CHEMBL445849 | — | Kd | = | 1.19 | nM | 8.92 |
| CHEMBL86328 | — | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL86430 | — | Kd | = | 1.34 | nM | 8.87 |
| CHEMBL315604 | — | Kd | = | 1.74 | nM | 8.76 |
| CHEMBL86848 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL263970 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL313445 | — | Kd | = | 4.35 | nM | 8.36 |
| CHEMBL315277 | — | Kd | = | 9.09 | nM | 8.04 |
| CHEMBL87808 | — | Kd | = | 32.1 | nM | 7.49 |
| CHEMBL66534 | — | Kd | = | 83.3 | nM | 7.08 |
| CHEMBL315344 | — | Kd | = | 208.0 | nM | 6.68 |