Assay Detail
Binding
CHEMBL675677
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Inhibition of [3H]-GBR-12,935 binding to dopamine transporter (DAT) of rat striatal membranes
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.43 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22216 | — | — | 1 | 6.77 |
| CHEMBL23033 | — | — | 1 | 6.77 |
| CHEMBL284002 | — | — | 1 | 6.76 |
| CHEMBL22743 | — | — | 1 | 6.47 |
| CHEMBL429065 | — | — | 1 | 6.12 |
| CHEMBL278809 | — | — | 1 | 6.09 |
| CHEMBL278165 | — | — | 1 | 6.02 |
| CHEMBL277045 | — | — | 1 | - |
| CHEMBL22436 | — | — | 1 | - |
| CHEMBL22183 | — | — | 1 | - |
| CHEMBL441022 | — | — | 1 | - |
| CHEMBL22643 | — | — | 1 | - |
| CHEMBL22259 | — | — | 1 | - |
| CHEMBL23034 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22216 | — | Ki | = | 171.0 | nM | 6.77 |
| CHEMBL23033 | — | Ki | = | 171.0 | nM | 6.77 |
| CHEMBL284002 | — | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL22743 | — | Ki | = | 339.0 | nM | 6.47 |
| CHEMBL429065 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL278809 | — | Ki | = | 818.0 | nM | 6.09 |
| CHEMBL278165 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL277045 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL22436 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL22183 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL441022 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL22643 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL22259 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL23034 | — | Ki | > | 1000.0 | nM | - |