Assay Detail
Binding
CHEMBL675706
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Binding affinity against dopamine agonist sites from rat brain corpus striatal preparations using [3H]ADTN
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.64 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31973 | — | — | 1 | 8.96 |
| CHEMBL27559 | — | — | 1 | 8.40 |
| CHEMBL283489 | — | — | 1 | 6.64 |
| CHEMBL27574 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31973 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL27559 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL283489 | — | Ki | = | 229.0 | nM | 6.64 |
| CHEMBL27574 | — | Ki | = | 278.0 | nM | 6.56 |