Assay Detail
Binding
CHEMBL675708
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Displacement of [3H]- apomorphine radioligand binding at the dopamine binding site of rat caudate
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and receptor binding studies relevant to the neuroleptic activities of some 1-methyl-4-piperidylidene-9-substituted-pyrrolo[2,1-b][3]benzazepine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.04 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL368578 | — | — | 1 | 8.18 |
| CHEMBL415761 | — | — | 1 | 8.17 |
| CHEMBL175508 | — | — | 1 | 8.14 |
| CHEMBL368357 | — | — | 1 | 7.96 |
| CHEMBL176365 | — | — | 1 | 7.81 |
| CHEMBL178376 | — | — | 1 | 7.48 |
| CHEMBL368475 | — | — | 1 | 7.06 |
| CHEMBL368413 | — | — | 1 | 6.82 |
| CHEMBL424967 | — | — | 1 | 6.75 |
| CHEMBL175154 | — | — | 1 | 6.73 |
| CHEMBL442783 | — | — | 1 | 4.75 |
| CHEMBL174649 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL368578 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL415761 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL175508 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL368357 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL176365 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL178376 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL368475 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL368413 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL424967 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL175154 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL442783 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL174649 | — | Ki | = | 23000.0 | nM | 4.64 |